The Effect of Treatment on Pulse Wave Indices of Proteinuira Cases

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Number of pages: 46-50
Year-Number: 2022-Volume: 4 Issue: 1

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Abstract

In proteinuria patients, the most significant reason of mortality is cardiovascular diseases caused by increased atherosclerosis. This study seeks to reveal the effects of the changes in the amount of proteinuria on the pulse waves of patients with proteinuria in a period of treatment of six months. 15 voluntary patients with proteinuria that applied to the outpatient clinic of Department of Nephrology, Faculty of Medicine, Cumhuriyet University for the first time enrolled in the study. PWV and AI measurements of the patients were taken by using a pressure-sensitive transduser by a single operator at the moment of diagnosis, third month, and six months after the diagnosis. Ten of the patients were female (66.7%), 5 were male (33.3%). The mean age of the patients was found to be 48.13±11.96 years. When the average of the patients’ micro total proteinuria (MTP), Pulse wave velocity (PWV) and augmentation index (AI) measurement are examined, it is observed that at the moment of diagnosis MTP: 4937,76 mg/day PWV: 7,07 m/s AI: 25,07 %, in the third month MTP: 2260,27 mg/day PWV: 6,79 m/s AI: 22,53 % and in the sixth month MTP: 2469,71 mg/day PWV: 7,18 m/s AI: 32,53 %. With our patients, there was a negative correlation between MTP and PWV in the third month (r=-0.621 p=0.014) and sixth month (r=-0.664 p=0.007), and the result is found to be statistically significant (p<0.05). In the first three-month period, it’s seen that MTP is decreased by treatment, and therefore PWV is decreased, also, and after that time, chronic stage occurs, and renal damage continued depending on the high proteinuria amount. We also observed an increase in PWV and  atherosclerosis. In order to demonstrate the relationship between proteinuria with PWV and atherosclerosis more clearly, there is a need for further studies which are long-term prospective and have a large number of patients.

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