We sought to evaluate the trends in age-standardized incidence rates of cancer by gender, age, and types in the Sivas province of Turkey between the years 2010-2019. Data were obtained from the Sivas Public Health Department Cancer Unit and the Cumhuriyet University Hospital Cancer Record Unit for the studied period. Data were presented as incidence rates in age, gender, and of the cancer types by using world age-standardized incidence rate (ASR-W) per 10 ⁵ populations. Of the 10928 registered new cases of cancer during the study period, 46% (5060) were female, and 54 % (5868) were male. The ASR-W of all cancers was 195.2 per 10 ⁵ in males and 168.3 per 10 ⁵ in females. The ASR-W was found as increased for both genders over the 10 year period. Among the cancer types in both genders the incidences were found as gastrointestinal system cancer (GIS) (ASR-W= 32.4), lung cancer (ASR-W = 22.1), breast cancer (ASR-W = 37.6), male genital system cancer (MGS) (ASR-W = 36.5), and thyroid cancer (ASR-W = 17.3) in decreasing frequency. Among the females breast (ASR-W = 37.6) cancer was the most common followed by thyroid (ASR-W= 27.3, GIS (ASR-W = 23.2), female genital system (FGS) (ASR-W = 18.2) and hematopoietic system (HPS) (ASR-W = 12.9) cancers. The greatest incidence in males was for GIS cancer (ASR-W = 41.9), followed by MGS (ASR-W = 36.2), lung (ASR-W = 35.9), urinary system (21.5) and HPS cancers (ASR-W = 17.3). The cancer incidence rate in males was found to be higher than in females from 2010 to 2019, and the incidences of some cancers were observed as decreased in both genders. As a result it is concluded that raising public awareness about the risk factors for cancer and the development of appropriate and effective screening programs to provide more reliable data for cancer prevention and control programs in Sivas province is necessary.