In this article, we aimed to investigate lung involvement in patients suffering from the new Coronavirus Disease 2019 (COVID-19) and to determine laboratory markers that indicate lung involvement. Patients diagnosed with COVID-19 pneumonia were included 90 patient in Group 1, while Group 2 comprised 60 patients in the control group and total of 150 patient. CCT scans of the study patients were transferred to the Intrasense Myrian® software (Myrian; Intrasense, Montpellier, France) and 3D models of the data were generated. Mean levels of D-dimer, fibrinogen and C-reactive protein (CRP) in Group 1 were 515±958 µg/L, 467±182 mg/dL and 5.67±5.46 mg/dL, respectively, whereas those in Group 2 were 129±120 µg/L, 345±113 mg/dL and 1.32±2.58 mg/dL, respectively (P<0.001). Right lung volume (RLV), left lung volume (LLV) and total lung volume (TLV) of Group 1 patients were 2419±554 cm3, 1857±634 cm3 and 3929±1297 cm3, respectively, while those measurements in Group 2 were 2483±503 cm3, 2118±535 cm3 and 4538±1079 cm3, respectively (P<0.001). Reduction of total lung volumes correlates with increase in levels of D-dimer and CRP and decrease in lymphocyte counts. Lung volumes of patients who develop Covid-19 pneumonia decrease. D-dimer, CRP and fibrinogen levels increase and lymphocyte levels decrease in these patients.