Obesity is expressed as increased body fat tissue mass. Obesity is the most frequent cause of insulin resistance. Insulin resistance leads to formation of type 2 diabetes mellitus within a period of 10-15 years. Due to this mechanism, there is a strong relationship between obesity and type 2 diabetes mellitus. This study aimed to compare obesity and type 2 diabetes mellitus, which occur with similar mechanisms, based on the inflammation they cause. Ninety-seven male and female individuals were included in the study. The participants were divided into three groups as the control group (n=31), obese group (n=33) and type 2 diabetes group (n=33). Their clinic biochemical tests were obtained retrospectively from their files and analyzed. The Neutrophil / Lymphocyte (N/L) ratios of the control, obese non-diabetic and type 2 diabetes mellitus groups were found respectively as (mean±SD) 1.76 ± 0.69, 1.95 ± 0.89 and 2.79 ± 2.16 (p=0.01). While N/L was numerically higher in the obese non-diabetic group in comparison to the control group, the difference was not statistically significant (p>0.05). This value was found to be significantly higher in the type 2 diabetes mellitus group than the other two groups (p<0.05). It is seen that type 2 diabetes mellitus development in obese non-diabetic individuals may be prevented by weight loss as a result of lifestyle changes, healthy and balanced diet, exercise and increased mobility, and this way, progression of systemic inflammation and formation of tissue and organ damage may be counteracted. In addition, if the transformation of insulin resistance into type 2 diabetes mellitus in obese individuals can be prevented, cardiovascular morbidity and mortality may decrease.