Pityriasis capitis simplex (Dandruff) is one of the most common scalp disorders with poor quality of life and pityriasic desquamation and pruritus on scalp. The main treatment options are antifungal agents and topical steroids. The aim of this study was to compare the clinical and symptomatic efficacy of strontium chloride hexahydrate 5% + licorice 1% combination (Storice®) with mometasone furoate 0.1%, a topical corticosteroid, in cases of pityriasis capitis simplex. 80 patients with a diagnodis of pityriasis capitis simplex were enrolled. 40 patients (20 males (50%), 20 females (50%)) were included in the mometasone furoate 0.1% group, and the remaining 40 patients (19 males (47.5%), 21 females (52.5%)) were included in the group of topical treatment agent (Storice®) consisting of strontium chloride hexahydrate 5% + licorice 1% combination. The clinical and symptomatic efficacy (pruritus and desquamation on scalp and life quality) of both agents were evaluated. Strontium chloride hexahydrate 5% + licorice 1% significantly reduces pruritus and improves quality of life by reducing clinical symptoms.