In this study, it was aimed to determine the symptoms experienced by patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy due to peritoneal carcinomatosis caused by colorectal cancer and the areas where their quality of life is affected. This study was carried using QLQ C30 and QLQ C29 form, out with patients who underwent SRC+HIPEC due to colorectal cancer in Cumhuriyet University Surgical Oncology Clinic. The QLQ-C30 quality of life scale is a globally used scale for patients with cancer. The scale consists of 30 questions for the past week. QLQ-CR29 is a quality of life questionnaire specifically designed for colorectal cancer. It consists of 29 questions evaluating disease symptoms, treatment side effects, body image, sexual status, and future prospects. The mean scores of the patients from the EORTC QLQ-C30 quality of life scale sub-dimensions; the general health score is 8.49 ± 2.54 functional scale 31.80 ± 2.18 and symptom scale 34.20 ± 3.32. When the ranking of the items in the QLQ-C30 scale according to their average scores is examined, the antecedents of vomiting, need for rest, financial difficulty, difficulty while walking for long and feeling fatigue are the predecessors that received the most average, respectively. When the ranking of the items on the QLQ-C29 scale according to their average scores is examined, frequent urination during the night, pain in the anal area, mucus in bowel movements, hair loss are the predecessors that received the most average, respectively. Although aggressive surgery is performed in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, side effects and loss of function do not reduce the quality of life of patients. As a result of multidisciplinary studies, we believe that more progress will be made in improving the quality of life of patients.