Potential effects of Apocynin against intestinal ischemia reperfusion-related oxidative damage was investigated in intestinal and lung tissues. Intestinal ischemia-reperfusion model was established. The superior mesenteric artery was occluded via an atraumatic clamp for 1 hour. Following ischemia, reperfusion was allowed for 2 hours. After the experimental processes, the animals were immolated, intestinal and lung tissue samples were removed. MPO activity and TOS, MDA, OSI, TNF-α, IL-1β levels raised in the ischemia-reperfusion group while TAS level and SOD activity diminished. TAS value and SOD activity elevated while MPO activity, OSI, TOS, TNF-α, IL-1β, and MDA levels decreased in low and high doses of Apocynin (20 mg/kg and 50 mg/kg) groups. Different doses of Apocynin administration demonstrated beneficial effects against intestinal ischemia reperfusion-induced oxidative damage in intestinal and lung tissues.