The aim of the present study was to investigate the predisposition to atopy in psoriasis vulgaris. Total serum immunoglobulin E (Ig E) and radioallergosorbent test (RAST) (Allergen-specific IgE Antibody test) were used in psoriasis patients in order to investigate this correlation. Forty-eight psoriasis patients and thirty-nine healthy control group were included in the study. Allergen-specific IgE antibody test for peripheral eosinophilia, serum total Ig E and Dermatophagoides (D.) pteronyssinus and D. farinae was applied to all the study group. The treatment, severity of the disease, age, gender, and the duration of the disease were taken into account in the patient group, no statistically significant difference was detected in terms of allergen-specific IgE antibody test for D. pteronyssinus and D. farinae (p>0.05). Serum IgE and eosinophil were seen at a higher rate in psoriasis patients (p < 0.05). Patients with psoriasis have elevated levels of serum eosinophil and serum total Ig E. Although there is no aeroallergen specific immune shift associated in relation to house dust mites, serum IgE and eosinophils may be important important in the course and follow-up of the disease.