The rate of water pipe smoking in adolescents and young adults is gradually increasing around the world. The aim of this systematic review was to evaluate the effectiveness of interventions performed to reduce water pipe smoking behaviors among adolescents. This review was conducted in Science Direct, Ebscohost (CINAHL Complete), OVID LWW, Springer Link, Wiley Interscience without limitation for the years in accordance with the Centre for Reviews and Dissemination 2009 guide developed by York University National Institute of Health Research. As a result of the review, two studies were included in the research. Video game-based interventions and visual campaigns were found to have positive results in reducing water pipe smoking behaviors.