Pregnancy rhinitis may lead predisposition to Obstructive Sleep Apnea Syndrome which is associated with critical comorbidities effecting both mother (preeclampsia, hypertension) and newborn (intrauterine growth retardation, low apgar score). We aim to unveil if nasal TREK-1 and AQP5 expression changes during pregnancy. We proposed that these two proteins may take part in the biomolecular background of Pregnancy Rhinitis. Twenty adult Wister albino female rats were enrolled into the study. Two groups constituted as 10 control (group A) and 10 pregnant (group B) rats. We sacrificed the rats at 21th day of gestation by intraperitoneal injection of 400mg/kg Na-pentobarbitone. Intracardiac blood sample was taken before the pulse died out. Serum estradiol (E2) and progesterone (PG) levels were determined by ELISA. Nasal septum with its mucoperichondrium was resected and sent for real time polymerase chain reaction testing. Relative TREK-1 (p=0.001) expression of group B was found to be significantly higher than group A. Relative AQP5 (p=0.003) expression was also found to be significantly higher in group B than group A. E2 was found to upregulate AQP5 expression (p=0.032) while downregulate TREK1 expression (p=-0.011). On the other hand, PG was also found to upregulate nasal AQP5 expression (p=0.024) but not TREK1 expression (p=-0.071). TREK1 and AQP5 take part in pregnancy related biomolecular changes of nasal mucosa. Namely, expression of TREK1 decreases while expression of AQP5 increases during pregnancy. These findings support the researchers asserting triggered allergy as the etiology of PR.