Acute lower extremity ischemia is an emergent situation with high rates of morbidity and mortality. In our study, we plan to investigate the effects of easily accessible and prognostic inflammatory markers for the prevention of complications and mortality in this clinical presentation in which early diagnosis and good management have great importance. Patients who underwent embolectomy between January 2010 and May 2018 were included in the study. The patients were divided into two groups with and without amputation. The patient’s demographic, clinical features, diagnosis and treatment methods were recorded. In addition, RDW, MPV values and ABI indices in the time of admission to the hospital were recorded and compared statistically. A total of 198 patients were included in the study. 156 (78.78%) of patients had no amputation and 42 patients (21.22%) had amputation in the study. RDW values of patients with amputation were found to be 15.72 ± 3.12, and RDW values of patients without amputation were found to be 14.81 ± 2.33 (p = 0.04). When the MPV values of the patients who underwent amputation were examined, 9.74 ± 1.2 was observed and 10.15 ± 1.23 were found in patients without amputation (p = 0.04). The preoperative ankle-brachial indexes of the patients in both groups were 0.51 ± 0.17 and 0.61 ± 0.12, respectively. RDW and MPV are important inflammatory markers in predicting prognosis in acute lower extremity ischemia.