Liver cancer is the second leading cause of death among other cancer types in the world. The use of preclinical models to develop new diagnostic technologies and new therapies for the prevention of liver metastasis is inevitable. Tea is a beverage that attracts the attention of many researchers because of the bioactive substances in its composition. In recent years, intensive researches have been conducted to examine the effects of green tea on health. The study aimed was to investigate the antiproliferative effect of green tea (Camelia Sinensis) extract on liver cell lines. XTT test was performed to investigate the cytotoxicity of HepG2 and WI-38 cell lines. In the study, IC50 was found to be 150 µg / mL in the WI-38 cell line of Green tea and 72 µg / mL in the HepG2 cell line. Green tea has an effect on HepG2 cell lines. And more work is needed in this area.