Ischemia Modified Albumin as a New Marker for Diagnosis of Early Pregnancy Losses

Author : - Dilek Erdem, Hasan Basri Savas, Neslihan Erdem, Sibel Kuloğlu Genç, Gamze Avcıoğlu
Number of pages : 222-227


The cause of a significant portion of pregnancy losses cannot be explained. Previous studies have suggested that trophoblast invasion and placental development occur in a relatively hypoxic environment during early pregnancy. In this study, we aimed to evaluate ischemic modified albumin (IMA) and thiol/disulfide ratios as an indicator of oxidative stress in early pregnancy losses. In this observational and prospective study, 30 healthy pregnant women, 30 pregnant women with early pregnancy loss in 6-14 weeks of pregnancy, and 30 healthy women with random sampling in reproductive age who applied to Alanya Alaaddin Keykubat University Education and Research Hospital Gynecology and Obstetrics Department were included. The patients’ total disulphide parameters (Native Thiol [NT], Disulfide [D], and Total Thiol [TT]), disulfide/native thiol (index 1), disulfide/total thiol (index 2), and native thiol/ total thiol (index 3) were studied. In statistical analyses, the level of disulfide was significantly lower in the early pregnancy losses (EPL) group compared to the control group. In the post-hoc analysis, the IMA level was significantly higher in the EPL and healthy pregnant group compared to the control group. In conclusion, the difference in IMA levels in our study and its compatibility with the literature suggests that this marker can be used in early pregnancy loss, however, in terms of thiol balance, there was no significant difference in native thiol and thiol in contrast to the literature, and in terms of disulfide, contradictory results are found. Thus, studies with larger populations are needed about the use of thiol and IMA in early pregnancy loss.


Early pregnancy loss, ischemia-modified albumin, thiol, disulfide.


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