Cisplatin-Induced Nephrotoxicity in Mouse Kidney Cortical Collection Duct Cells: Protective Role of Curcumin

Author : Bilal ÇİĞ
Number of pages : 117-122

Abstract

The use of Cisplatin in chemotherapeutic treatment is limited to nephrotoxicity. It is stated that cytotoxic DNA platinum inserts, platinum transport mechanisms and pro-apoptotic DNA damage are the main causes of platinum-based renal toxicity. We have discussed the oxidative mitochondrial stress and apoptosis states that occur to understand the basic mechanism of this situation. Various antioxidants have been proposed in Cisplatin (Cisp) induced nephrotoxicities. In this study, we aimed to investigate the effects of curcumin (CurC), a powerful antioxidant, against this nephrotoxicity. Groups were created as Control, Cisplatin, Curcumin and Cisp+CurC. While lipid peroxidation levels were significantly higher in Cisp groups, GSH and GSH-Px values were low. Treatment with curcumin reversed these values. Reactive oxygen species (ROS), Mitochondrial membrane depolarization, Apoptosis, caspase-3, -9 values were also significantly increased in Cisp groups. Curcumin brought these values back to normal. As a result, these data contribute to the understanding of molecular mechanisms in Cisp-induced nephrotoxicity. Considering curcumin in eliminating this toxicity may prevent possible renal failure especially in the development of treatment strategies in cancer patients.

Keywords

Cisplatin, Nefrotoksisite, Curcumin, mpkCCDcl4

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