Although it is known that the level of health literacy is effective in determining the direction of individuals' attitudes towards their own health, its effect on the attitudes towards COVID-19 vaccine is not yet known exactly. The aim of this study is to determine the relationship between health literacy and attitudes towards COVID-19 vaccine in adult individuals. This study is a cross-sectional design. The study was conducted with literate individuals aged 18 or over (N=210), in Turkey. The data were collected online using personal information form, Attitudes Towards COVID-19 Vaccine (ATV-COVID-19) Scale, and Health Literacy Scale (HLS). HLS score of the women and unemployed ones were high (p<0.05). ATV-COVID-19 scores of those with chronic diseases in their families were higher. (p<0.05). Moreover, scores of some subscales of HLS and ATV-COVID-19 were also correlated (p<0.05). It was determined that the adult individuals’ health literacy and attitudes towards COVID-19 vaccine were positively correlated. It will be possible to reach higher community vaccination levels by planning activities that will increase health literacy throughout the society.