Sepsis is a hard clinical condition to diagnose and treat; but it occasionaly happens and it is an important life threatning health condition. New diagnostic criteriae has been released in 2016. The aim of this study was to show the efficiency of Surviving Sepsis Campaign diagnostic parameters and prognostic factors. 100 patients in intensive care unit of Izmir Ataturk Education and Research Hospital II. Anesthesiology and Reanimation ICU were included. The data of the patients were recorded according to the 2001 Survining Sepsis Campaign Criteria during the time interval of the study. Each parameter was assessed separately in both the survived (Group I) and deceased (Group II) patients. The specificity and sensitivity was calculated for each parameter with statistical significance. A total of 100 patients were evaluated. The mortality of sepsis patients was 46%. Among the SSC diagnostic criteria; respiratory rate, mental status, elevation of CRP and procalcitonin, presence of arterial hypoxemia, presence of acute oliguria, thrombocytopenia, aPTT elevation, hypotension and lactate elevation were determined as prognostic factors. Only the specificity and sensitivities of CRP (82% and 95%, respectively) and of procalcitonin (53% and 82%, respectively) were high. The 2001 SSC diagnostic criteria are useful in determining mortality in patients with sepsis in intensive care unit. Nevertheless, pre-screening of high-risk patients, avoidance of unnecessary admissions, and creating guidelines for approaching the patients with this disease will reduce mortality and morbidity rates.